Labex EPIGENMED Montpellier, France

 Hematopoiesis and Immunotherapy

 Naomi TAYLOR

 IGMM - UMR 5535

1919, route de Mende, 34293

Phone:+33 4 34 35 96 28

Email: taylor@igmm.cnrs.fr

Website

The major research axes of our group are:

- T cell homeostasis, differentiation and metabolism in the context of genetic/acquired immunodeficiencies and cancer immunotherapy

-Modulating T cell differentiation by stem cell and gene therapies targeting the thymus

-Role of the GLUT1 glucose transporter in hematopoietic stem cell differentiation, activation and retroviral infection

-Erythrocyte GLUT1 expression: Evolutionary link to defective vitamin C synthesis

-Role of conditioning regimens in shaping the homeostasis of adoptively transferred T cells: Enhancing anti-tumor immunotherapy

-Normal and pathological human lymphopoeisis: Roles of the related ZAP-70 and Syk protein tyrosine kinases

-Studies of human immunodeficiencies

Keywords: Hematopoiesis, T cells, gene and cell therapies, metabolism, immunomodulation

Main publications

• Manel, N., Kim, F.,Kinet, S., Taylor, N., Sitbon, M.* and Battini, J.L.* 2003. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell, 14:449-459. (*co-senior authors; featured in in Nat Med, News and Views, 2004)
• Adjali, O., Marodon, M., Steinberg, M., Mongellaz, C., Vaslin-Thomas, V., Jacquet, C., N. Taylor* and D. Klatzmann*. 2005. Intrathymic gene transfer via a T cell-specific lentiviral vector restores T cell differentiation in ZAP-70 deficient mice. J. Clin. Invest., 115:2287-2295 (*co-senior authors; previewed by Seggewiss/Dunbar in JCI; and featured by Candotti et al. in Gene Ther, 2006)
• Swainson, L., Kinet, S., Manel, N., Battini, J.L., Sitbon, M. and N. Taylor. 2005. Glucose transporter 1 expression characterizes a novel population of cycling CD4+CD8+ human thymocytes with high CXCR4-induced chemotaxis. Proc. Natl. Acad. Sci. USA., 102:12867-12872.
• Adjali, O., Vicente, R., Ferrand, C., Jacquet, C., Mongellaz, C., Tiberghien, P., Chebli, K., Zimmermann, V., and N. Taylor. 2005. Intrathymic administration of hematopoietic progenitor cells enhances T cell reconstitution in ZAP-70 severe combined immunodeficiency. Proc. Natl. Acad. Sci. USA, 102:13586-13591.
• Swainson, L., Kinet, S., Mongellaz, C., Sourisseau, M., Henriquez, T. and N. Taylor. 2007. IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway. Blood, 109(3):1034-42.
• Montel-Hagen, A, Kinet, S, Manel, N, Mongellaz, C, Prohaska, R, Battini, JL, Delaunay, J, Sitbon, M, and N. Taylor 2008. Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C. Cell, 132:1039-1048. (previewed in Cell by Troadec and Kaplan)
• Montel-Hagen, A., Blanc, L., Jacquet, C., Boyer-Clavel, M., Vidal, M., Sitbon, M. and N. Taylor. 2008. The Glut1 and Glut4 glucose transporters are differentially expressed during perinatal and postnatal erythropoiesis, Blood, 112:4729-38.
• Montel-Hagen, A, Kinet, S, Manel, N, Mongellaz, C, Prohaska, R, Battini, JL, Delaunay, J, Sitbon, M, and N. Taylor. 2009. Species diversity in GLUT expression and function. Cell 137: 201-202 (correspondence with on-line supplemental data)
• Vicente, R., Adjali, O., Jacquet, C., Zimmermann, V.* and N. Taylor*. 2010. Intrathymic transplantation of bone marrow derived progenitors provides long-term thymopoiesis. Blood 115:1913-1920 (*co-senior authors)
• Loisel-Meyer, S., Swainson, L., Craveiro, M., Oburoglu, L., Mongellaz, C., Costa, C., Martinez, M., Sahaf, B., Herzenberg, L.A., Herzenberg, L.A., Cosset, F.L., Battini, J.L., Sitbon, M., Kinet, S., Verhoeyen, E. and N. Taylor. 2012. Glut1-mediated glucose transport regulates HIV-1 infection. Proc. Natl. Acad. Sci. USA in press.