Genetic diversity of HIV/SIV and emerging infections

 Martine PEETERS

 TransVIHMI - UMI 223

 911, avenue Agropolis, 34396 Montpellier

Phone: +33 4 67 41 62 97

Email: martine.peeters@ird.fr

Website

UMI 233 is a multidisciplinary research unit. The team conducted by Martine Peeters is working on the genetic diversity of HIV and its implication for human health in particular in the field of resistance to antiretroviral drugs.This unit is a WHO reference laboratory for HIV drug resistance and molecular epidemiology. The laboratory developed in Cameroon is also a WHO national reference. The team is PI of international studies on HIV drug resistance in resource limited countries.

With the support of NIH and ANRS the team is conducting reference studies on the origin of AIDS and the risk of emerging new anthropozoonosis. Studies are not limited to retroviruses, for instance the team is leader of an ANR project on the origin and diversity of plasmodium falciparum in non-human primates.

Keywords: HIV, SIV, emerging infections, malaria, drug resistance

Last publications

• Aghokeng AF, Kouanfack C, Peeters M, Mpoudi-Ngole E, and Delaporte E Successful Integrase Inhibitor-Based Highly Active Antiretroviral Therapy for a Multidrug-Class-Resistant HIV Type 1 Group O-Infected Patient in Cameroon. AIDS Res Hum Retroviruses (2013); 29(1):1-3.
• Ayouba A, Mouacha F, Learn GH, Mpoudi-Ngole E, Rayner JC, Sharp PM, Hahn BH, Delaporte E, and Peeters M Ubiquitous Hepatocystis infections, but no evidence of Plasmodium falciparum-like malaria parasites in wild greater spot-nosed monkeys (Cercopithecus nictitans). Int J Parasitol (2012); 42(8):709-13.
• Chen S, Cai W, He J, Vidal N, Lai C, Guo W, He H, Chen X, Fu L, Peeters M, Delaporte E, Andrieu J-M, and Lu W Molecular Epidemiology of Human Immunodeficiency Virus Type 1 in Guangdong Province of Southern China. PLoS ONE (2012); 7(11):e48747.
• Djoko CF, Wolfe ND, Aghokeng AF, Lebreton M, Liegeois F, Tamoufe U, Schneider BS, Ortiz N, Mbacham WF, Carr JK, Rimoin AW, Fair JN, Pike BL, Mpoudi-Ngole E, Delaporte E, Burke DS, and Peeters M Failure to Detect Simian Immunodeficiency Virus Infection in a Large Cameroonian Cohort with High Non-human Primate Exposure. Ecohealth (2012); 9(1):17-23.
• Etienne L, Locatelli S, Ayouba A, Esteban A, Butel C, Liegeois F, Aghokeng A, Delaporte E, Mpoudi Ngole E, and Peeters M Noninvasive follow-up of simian immunodeficiency virus infection in wild-living nonhabituated Western lowland gorillas in cameroon. J Virol (2012); 86(18):9760-72.
• Jordan MR, Bennett DE, Wainberg MA, Havlir D, Hammer S, Yang C, Morris L, Peeters M, Wensing AM, Parkin N, Nachega JB, Phillips A, De Luca A, Geng E, Calmy A, Raizes E, Sandstrom P, Archibald CP, Perriens J, McClure CM, Hong SY, McMahon JH, Dedes N, Sutherland D, and Bertagnolio S Update on World Health Organization HIV drug resistance prevention and assessment strategy: 2004-2011. Clin Infect Dis (2012); 54 Suppl 4:S245-9.
• Jung M, Leye N, Vidal N, Fargette D, Diop H, Toure Kane C, Gascuel O, and Peeters M The Origin and Evolutionary History of HIV-1 Subtype C in Senegal. PLoS One (2012); 7(3):Epub 2012 Mar 28.
• Li Y, Ndjango JB, Learn GH, Ramirez MA, Keele BF, Bibollet-Ruche F, Liu W, Easlick JL, Decker JM, Rudicell RS, Inogwabini BI, Ahuka-Mundeke S, Leendertz FH, Reynolds V, Muller MN, Chancellor RL, Rundus AS, Simmons N, Worobey M, Shaw GM, Peeters M, Sharp PM, and Hahn BH Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir. J Virol (2012); 86(19):10776-91.
• Liegeois F, Boue V, Mouacha F, Butel C, Mve-Ondo B, Pourrut X, Leroy E, Peeters M, and Rouet F New STLV-3 strains and a divergent SIVmus strain identified in non-human primate bushmeat in Gabon. Retrovirology (2012); 9(1):28 [Epub ahead of print].
• Liegeois F, Vella C, Eymard-Duvernay S, Sica J, Makosso L, Mouinga-Ondeme A, Mongo AD, Boue V, Butel C, Peeters M, Gonzalez JP, Delaporte E, and Rouet F Virological failure rates and HIV-1 drug resistance patterns in patients on first-line antiretroviral treatment in semirural and rural Gabon. J Int AIDS Soc (2012); 15(2):17985.
• Locatelli S, and Peeters M Cross-species transmission of simian retroviruses: how and why they could lead to the emergence of new diseases in the human population. Aids (2012); 26(6):659-73.
• Locatelli S, and Peeters M Non-Human Primates, Retroviruses, and Zoonotic Infection Risks in the Human Population. Nature Education Knowledge (2012); 3(9):9.
• Monleau M, Aghokeng AF, Nkano BA, Chaix ML, and Peeters M Drug resistance mutations of HIV-1 non-B viruses to integrase inhibitors in treatment-naive patients from sub-Saharan countries and discordant interpretations. AIDS Res Hum Retroviruses (2012); 28(9):957-960.
• Peeters M, and Delaporte E Simian retroviruses in African apes. Clin Microbiol Infect (2012); 18(6):514-20.
• Sabrina Locatelli, and Martine Peeters Non-Human Primates, Retroviruses, and Zoonotic Infection Risks in the Human Population. Nature Education Knowledge (2012); 3(6).
• Sauter D, Unterweger D, Vogl M, Usmani SM, Heigele A, Kluge SF, Hermkes E, Moll M, Barker E, Peeters M, Learn GH, Bibollet-Ruche F, Fritz JV, Fackler OT, Hahn BH, and Kirchhoff F Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. PLoS Pathog (2012); 8(12):e1003093.
• Somda A, Sangare L, Soro M, Yameogo S, Bazie B, Bigirimana F, Bertagnolio S, Peeters M, Mouacha F, Rivera AM, Jordan MR, and Sanou MJ Surveillance of transmitted drug-resistant HIV among young pregnant women in Ouagadougou, Burkina Faso. Clin Infect Dis (2012); 54 Suppl 4:S317-9.
• Switzer WM, Tang S, Ahuka-Mundeke S, Shankar A, Hanson DL, Zheng H, Ayouba A, Wolfe ND, Lebreton M, Djoko CF, Tamoufe U, Esteban A, Heneine W, Peeters M, Wright LL, Muyembe-Tamfum JJ, Wemakoy EO, Mulembakani P, Hoff NA, and Rimoin AW Novel simian foamy virus infections from multiple monkey species in women from the Democratic Republic of Congo. Retrovirology (2012); 9:100.
• Vidal N, Diop H, Montavon C, Butel C, Bosch S, Ngole EM, Toure-Kane C, Mboup S, Delaporte E, and Peeters M. A novel multiregion hybridization assay reveals high frequency of dual inter-subtype infections among HIV-positive individuals in Cameroon, West Central Africa. Infect Genet Evol (2012); (http://dx.doi.org/10.1016/j.meegid.2012.11.017 ).