Parent Category: Laboratoires Published: Thursday, 16 February 2012

MYELIN Avenir Team

 

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Nicolas TRICAUD

 

 INM - U 1051

 80, rue Augustin Fliche, 34091 Montpellier

 

Phone: + 33 4 99 63 61 40

Email : nicolas.tricaud@inserm.fr

 

Website

 

 

Fast nerve conduction requires neurons to be wrapped by myelinating cells. This myelination process is the result of an intimate collaboration between both cell types. The importance of myelination is underlined by the numerous acquired and inherited neuropathies such as Charcot-Marie-Tooth diseases or multiple sclerosis that result from the loss of the myelin sheath.

Our goal is to understand the molecular basis of myelination and demyelination processes both in myelinating cells and axons and to investigate how these molecular pathways could be involved in the aetiology of demyelinating neuropathies.

 

Keywords : myelin, Schwann cells, cell polarity, viral vector, gene therapy

 

 

Main publications

  • Bartolami S, Tricaud N. More myelin is not necessarily good. Med Sci (Paris). 28(4):341-3 (2012).
  • Jacob C, Christen CN, Pereira JA, Somandin C, Baggiolini A, Lötscher P, Ozçelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P and Suter U. HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nat. Neurosci. 14:429-436 (2011).
  • Cotter L, Özçelik M, Jacob C, Pereira J.A, Locher V, Baumann R, Relvas J.B, Suter U and Tricaud N. Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination. Science 268:1415-18 (2010).
  • Özçelik M, Cotter L, Jacob C, Pereira J.A, Relvas J.B, Suter U and Tricaud N. Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J. Neurosci. 30(11): 4120-31 (2010).
  • E. Arnaud, J. Zenker, AS. de Preux Charles, C. Stendel, A. Roos, JJ. Médard, N. Tricaud, J. Weis, U. Suter, J. Senderek and R. Chrast. SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc. Natl. Acad. Sci. USA 106(41): 17528-33 (2009).
  • J.A. Pereira, Y. Benninger, R. Baumann, A.F. Gonçalves, M. Özçelik, T. Thurnherr, N. Tricaud, D. Meijer, R. Fässler, U. Suter, and J.B. Relvas. Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J. Cell Biol. 185(1): 147-61 (2009).
  • Perrin-Tricaud C, Rutishauser U, Tricaud N. P120 catenin is required for thickening of Schwann cell myelin. Mol. Cell. Neurosci. 35: 120-129 (2007).
  • Tricaud N, Perrin-Tricaud C, Bruses J, Rutishauser U. Adherens junctions in myelinating Schwann cells stabilize Schmidt-Lanterman incisures via recruitment of p120 catenin to E-cadherin. J. Neurosci. 25(3): 3259-3269 (2005).
  • Bouzidi M, Tricaud N, Giraud P, Kordeli E, Caillol G, Deleuze C, Couraud F, Alcaraz G. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrin. In vitro mapping of the interacting domains and association in synaptosomes. J. Biol. Chem. 277: 28996-29004 (2002).
  • Tricaud N, Marchot P, Martin-Eauclaire MF. On the kaliotoxin and dendrotoxin binding sites on rat brain synaptosomes. Toxicon 38: 1749-1758 (2000).
  • Sampo B, Tricaud N, Leveque C, Seagar M, Couraud F, Dargent B. Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels. Proc. Natl. Acad. Sci. USA 97(7): 3666-3671 (2000) Co-first authors.

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