Parent Category: Laboratoires Published: Friday, 25 January 2013

Retroviruses, Envelopes and Metabolic Markers





 IGMM - UMR 5535

 1919, route de Mende, 34293 Montpellier


Phone: +33(0)4 34 35 96 40 or 42





We are interested in all aspects of mammalian retrovirus infections, including their interactions with cellular factors and their co-evolution with the host. Our latest discoveries on retroviral envelopes (Env) and their receptors opened us to cellular metabolism. Our projects thus encompass five main themes bridging mostly over Axis 2 and 3 of EpiGenMed :

1. Retrovirus innate restriction factors and cross-species transmission
2. Exogenous and endogenous retrovirus envelopes and receptors
3. XPR1 and phosphate metabolism
4. Nutrient transporters and cell differentiation
5. Metabolic biomarkers of pathological processes

Keywords: Retrovirus ; viral envelopes ; receptors ; transporters ; metabolism




Main publications

  • Anheim§, M., U. Lopez-Sanchez§, D. Giovannini, A. C. Richard, J. Touhami, L. N'Guyen, G. Rudolf, A. Thibault-Stoll, T. Frebourg, D. Hannequin, D. Campion, J. L. Battini*, M. Sitbon*, and G. Nicolas*. 2016. XPR1 mutations are a rare cause of primary familial brain calcification. J. Neurol. 2016 May 26. [Epub ahead of print].
  • Jeziorski, E., V. Foulongne, C. Ludwig, D. Louhaem, M. Rodiere, M. Sitbon*, and V. Courgnaud*. 2016. Searching for Common Mammalian Retroviruses in Pediatric Idiopathic Diseases. Viruses 8(3). pii: E86.
  • Legati§, A., D. Giovannini§, G. Nicolas, U. Lopez-Sanchez, B. Quintans, J. R. Oliveira, R. L. Sears, E. M. Ramos, E. Spiteri, M. J. Sobrido, A. Carracedo, C. Castro-Fernandez, S. Cubizolle, B. L. Fogel, C. Goizet, J. C. Jen, S. Kirdlarp, A. E. Lang, Z. Miedzybrodzka, W. Mitarnun, M. Paucar, H. Paulson, J. Pariente, A. C. Richard, N. S. Salins, S. A. Simpson, P. Striano, P. Svenningsson, F. Tison, V. K. Unni, O. Vanakker, M. W. Wessels, S. Wetchaphanphesat, M. Yang, F. Boller, D. Campion, D. Hannequin, M. Sitbon, D. H. Geschwind, J. L. Battini*, and G. Coppola*. 2015. Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nat Genet 47:579-581.
  • Oburoglu, L., S. Tardito§, V. Fritz§, S. C. de Barros§, P. Merida§, M. Craveiro, J. Mamede, G. Cretenet, C. Mongellaz, X. An, D. Klysz, J. Touhami, M. Boyer-Clavel, J. L. Battini, V. Dardalhon, V. S. Zimmermann, N. Mohandas, E. Gottlieb, M. Sitbon, S. Kinet*, and N. Taylor*. 2014. Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell Stem Cell 15:169-184.
  • Petit§, V., G. Massonnet§, Z. Maciorowski, J. Touhami, A. Thuleau, F. Nemati, J. Laval, S. Chateau-Joubert, J. L. Servely, D. Vallerand, J. J. Fontaine, N. Taylor, J. L. Battini, M. Sitbon*, and D. Decaudin*. 2013. Optimization of tumor xenograft dissociation for the profiling of cell surface markers and nutrient transporters. Lab Invest 93:611-621.
  • Mamede, J. I., M. Sitbon, J.-L. Battini, and V. Courgnaud. 2013. Heterogeneous susceptibility of circulating SIV isolates to HIV capsid-interacting factors. Retrovirology 10:77.
  • Laval, J., J. Touhami, L. A. Herzenberg, C. Conrad, N. Taylor, J. L. Battini, M. Sitbon*, and R. Tirouvanziam*. 2013. Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression. J Immunol 190:6043-6050.
  • Giovannini, D., J. Touhami, P. Charnet, M. Sitbon*, and J. L. Battini*. 2013. Inorganic Phosphate Export by the Retrovirus Receptor XPR1 in Metazoans. Cell Rep 3:1866-1873.
  • Craveiro, M., I. Clerc, M. Sitbon*, and N. Taylor*. 2013. Metabolic pathways as regulators of HIV infection. Curr Opin HIV AIDS 8:182-189.
  • Courgnaud, V., J. L. Battini, M. Sitbon, and A. L. Mason. 2010. Mouse retroviruses and chronic fatigue syndrome: Does X (or P) mark the spot? Proc Natl Acad Sci U S A 107:15666-15667.

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