Eric Soler

Parent Category: ROOT Published: Wednesday, 14 December 2016

 Molecular Homatopoiesis





 IGMM - UMR 5535

 1919, route de Mende, 34293 Montpellier


Phone: +33 4 34 35 96 57 (-55)







The Laboratory of Molecular Hematopoiesis investigates the mechanisms regulating spatio-temporal control of gene expression, with particular emphasis on 3D genome organization. We combine proteomics and functional genomics tools to investigate the relationships existing between chromosome folding, genome architecture and gene expression during cellular differentiation and development.

We use red blood cell differentiation as a model to conduct epigenomic studies of the normal differentiation process. In addition, we are focusing on different erythroid disorders such as beta thalassemias and sickle cell anemia, which are among the most common inherited genetic disorders in humans and acute erythroid leukemias, a rare but particularly aggressive subtype of leukemia for which therapeutic options are dramatically limited.

The goal is to improve our understanding of the basic principles of chromatin folding, and the associated changes in response to extracellular signals or in disease states, with the long-term goal of being able to therapeutically manipulate genome topology in clinical settings.

Keywords: Transcription, Chromatin looping, erythropoiesis, leukemia, thalassemia.



Main publications : 


Unbiased Interrogation of 3D Genome Topology Using Chromosome Conformation Capture Coupled to High-Throughput Sequencing (4C-Seq). Brouwer RW, van den Hout MC, van IJcken WF, Soler E, Stadhouders R. Methods Mol Biol. 2017;1507:199-220.

Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Stadhouders R, Cico A, Stephen T, Thongjuea S, Kolovos P, Baymaz HI, Yu X, Demmers J, Bezstarosti K, Maas A, Barroca V, Kockx C, Ozgur Z, van Ijcken W, Arcangeli ML, Andrieu-Soler C, Lenhard B, Grosveld F, Soler E. Nat Commun. 2015 Nov 23;6:8893.

The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. Cell Stem Cell. 2015 Sep 3;17(3):287-99.

Long-range gene regulation and novel therapeutic applications. van den Heuvel A, Stadhouders R, Andrieu-Soler C, Grosveld F, Soler E. Blood. 2015 Mar 5;125(10):1521-5. doi: 10.1182/blood-2014-11-567925.

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers. Stadhouders R, Aktuna S, Thongjuea S, Aghajanirefah A, Pourfarzad F, van Ijcken W, Lenhard B, Rooks H, Best S, Menzel S, Grosveld F, Thein SL, Soler E. J Clin Invest. 2014 Apr;124(4):1699-710.

Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions. Stadhouders R, de Bruijn MJ, Rother MB, Yuvaraj S, Ribeiro de Almeida C, Kolovos P, Van Zelm MC, van Ijcken W, Grosveld F, Soler E, Hendriks RW. PLoS Biol. 2014 Feb 18;12(2):e1001791.

r3Cseq: an R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data. Thongjuea S, Stadhouders R, Grosveld FG, Soler E, Lenhard B. Nucleic Acids Res. 2013 Jul;41(13):e132.

Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions. Stadhouders R, Kolovos P, Brouwer R, Zuin J, van den Heuvel A, Kockx C, Palstra RJ, Wendt KS, Grosveld F, van Ijcken W, Soler E. Nat Protoc. 2013 Mar;8(3):509-24.

Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. Stadhouders R, Thongjuea S, Andrieu-Soler C, Palstra RJ, Bryne JC, van den Heuvel A, Stevens M, de Boer E, Kockx C, van der Sloot A, van den Hout M, van Ijcken W, Eick D, Lenhard B, Grosveld F, Soler E. EMBO J. 2012 Feb 15;31(4):986-99.

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